Metabolism of Biphenyl and 4Chlorobiphenyl in the Rabbit*
نویسندگان
چکیده
The ability of the rabbit to metabolize naphthalene and chlorinated naphthalene was markedly influenced by the degree of halogenation of the compound according to Cornish and Block (2). Naphthalene is related structurally to biphenyl, in which a coaxial linkage connecta two phenyl molecules. Whethe? the presence of a chlorine atom in biphenyl also alters the metabolism of this compound as it, does in the case of naphthalene has not been reported. Stroud (3) and West, et ~2. (4) have studied the metabolism of unsubstituted biphenyl respectively in rabbits and in rats. The present investigation is a comparative metabolic study of the urinary end-products of biphenyl and 4chlorobiphenyl in the rabbit.
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